Entries by Academic Web Pages

New tool may help researchers predict cognitive decline with Parkinson’s disease

A new tool from researchers at Harvard Medical School may allow investigators to predict cognitive decline in people with Parkinson’s disease (PD), which could help design clinical trials and test new therapies. The tool uses an algorithm combining varied personal details — age at onset, baseline score on the Mini Mental State Examination, years of education, motor exam score, sex, depression, and GBA mutation status.

Lindquist leaves behind Parkinson’s interactome as her parting gift

For the many genes and proteins involved in Parkinson’s disease, it’s a small world. Basically, they are all at least friends of friends. Leveraging connections between yeast genes to infer links between human genes, researchers led by the late and beloved Susan Lindquist of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, have just made that clear.

Mutations in GBA gene linked to Parkinson’s cognitive decline

As we learn more about genetic connections to Parkinson’s disease (PD), researchers strive to understand the biological and functional impact of these variants. What does having a GBA mutation really mean for someone? Complicating matters further is that there are many different mutations on one gene. How does the type of mutation on that gene […]

Sans synuclein tetramers, mice mimic Parkinson’s disease

A new model of Parkinson’s disease re-creates key features of the disorder, and helps steady one disputed theory of what causes it. Mice carrying mutations that disrupt physiological tetramers of the α-synuclein protein develop brain pathology and neurodegeneration typical of PD, according to work from the lab of Dennis Selkoe at Brigham and Women’s Hospital […]