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Lindquist leaves behind Parkinson’s interactome as her parting gift

For the many genes and proteins involved in Parkinson’s disease, it’s a small world. Basically, they are all at least friends of friends. Leveraging connections between yeast genes to infer links between human genes, researchers led by the late and beloved Susan Lindquist of the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, have just made that clear.

Sans synuclein tetramers, mice mimic Parkinson’s disease

A new model of Parkinson’s disease re-creates key features of the disorder, and helps steady one disputed theory of what causes it. Mice carrying mutations that disrupt physiological tetramers of the α-synuclein protein develop brain pathology and neurodegeneration typical of PD, according to work from the lab of Dennis Selkoe at Brigham and Women’s Hospital […]

Form and function: What makes α-synuclein toxic?

Changes in shape and structure can turn a well-behaved cellular protein into something altogether more sinister, but in many cases researchers do not know exactly which modifications are at fault. At the 12th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 18-22 in Nice, France, speakers grappled with what makes α-synuclein go rogue. Researchers […]